Whole Room Disinfection in Biosafety and GMP Rooms

Automated 3D room disinfection by aerosol

Sanosil Laboratory (83)

Case Study: Aerosol Disinfection in BSL Laboratories

Class 4 Biosafety Laboratory, Switzerland: Our institute regularly needs to completely disinfect laboratory and animal rooms as well as hygiene sluices. We sought alternatives to formaldehyde fumigation and tested the Sanosil Q-Jet system. In addition to bacterial spore indicators, we successfully tested and validated it with foot-and-mouth disease viruses for our purposes. Sanosil Q-Jet with Sanosil S015 is a safe and efficient alternative to other fumigation methods, and we can recommend it without reservations.

To case study

Automated Room Disinfection in Laboratory and GMP Rooms

In laboratories, contamination of samples by airborne germs or cross-contamination is a frequent issue. This may necessitate the disposal and repetition of entire experiment series. Additionally, there is a risk of accidental release of pathogenic germs, endangering human health and the environment.

In pharmaceutical production rooms, there is a danger of production batches being contaminated with germs.

Aerosol disinfection is an effective supplement to conventional surface disinfection in room hygiene, helping to close hygiene gaps. During aerosol disinfection, disinfectants are dispersed as fine particles into the air, thoroughly disinfecting even hard-to-reach areas such as the room air and inaccessible surfaces. This method ensures comprehensive decontamination of surfaces that might otherwise be overlooked.

Sanosil disinfectant for aerosol disinfection application: a good choice!

The combination of purpose-designed devices (Sanosil Q-Jet Series) and the appropriate Sanosil disinfectants has proven to be excellent for 3D whole-room disinfection for over 25 years.

  • Premium products with boosted hydrogen peroxide
  • Verified effectiveness (Standard EN 17272 / AFNOR NFT 72-281)
  • In use for over 25 years
  • Products manufactured to ISO 13485 Medical Standard available
  • Compatible with Sanosil Q-Jet devices or similar devices proven for automated aerosol/cold fog disinfection

The Sanosil Bestsellers for 3D-aHP Whole-Room Disinfection

Devices

Sanosil Q-Jet C10

Compact aerosol device for 3D hygiene in rooms from 6 to 100m³

  • Modern 3D full-room disinfection through an automated, airborne system (aerosol disinfection)
  • Portable, easy to transport and operate
  • Compressor technology: quiet and reliable
  • Ideal for rooms/smaller spaces up to 100m³

Sanosil Q-Jet CT20

High-end aerosol device for automated 3D room and air disinfection

  • Modern 3D full-room disinfection using automated, airborne system (aerosol disinfection)
  • With compressor and switchable turbine for small to large rooms
  • Dosing capability beyond the saturation limit of room air thanks to automatic switchable step function
  • For demanding tasks such as disinfection under EN 17272 conditions

 

Aerosol- Disinfectants

Sanosil S015

Disinfectant for demanding aerosol applications with AFNOR NFT 72-281 certificate

  • Effectiveness against bacteria, viruses, yeasts, fungi, and spores
  • Automatic room disinfection application with Sanosil Q-Jet devices or equivalent/similar functioning devices
  • With catalytically enhanced hydrogen peroxide (decomposes into water and oxygen)
  • Alternative to VPHP (vaporized hydrogen peroxide) – without ADR restrictions

 

Sanosil QDis8

Disinfectant (without silver ions) for demanding aerosol applications with EN - 17272 test

  • Effectiveness tested according to EN 17272 against bacteria, viruses, yeasts, and fungi
  • Automatic room disinfection application with Sanosil Q-Jet devices or equivalent/similar functioning devices
  • With synergistically enhanced hydrogen peroxide (decomposes into water and oxygen), silver-free
  • Alternative to VPHP (vaporized hydrogen peroxide) – without ADR restrictions

Brochures

Broschüre-Q-Jet C10-EN
Download
Broschüre-Q-Jet CT20-EN
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Broschüre-S015 Aerosol-EN
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SDS-QDis8-EN
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Whole-Room Disinfection in BSL Laboratories and the Pharmaceutical Sector: Frequently Asked Questions (FAQ)

Q: Is automated airborne disinfection system (AADS) suitable for cleanrooms?

A: Yes, the EU GMP Annex 1 of 2022 explicitly recommends it.

Q: What is the difference between hydrogen peroxide aerosol systems (aHP) and vaporized H2O2 systems (VpHP)?

A:

  • VpHP (Vaporized H2O2)
    Vaporizes a 30-35% aqueous hydrogen peroxide solution to create a mixture of hot air and hydrogen peroxide vapor.
  • aHP (Aerosolized Hydrogen Peroxide)
    Produces a mist by aerosolizing a solution with a lower concentration of hydrogen peroxide (less than 8%) and enhancing chemical additives (e.g., catalytically active silver ions, stabilizers).

Q: What are the advantages of Sanosil aerosol disinfection (aHP) compared to vaporized hydrogen peroxide (VpHP)?

A:

  • Less sensitive to small traces of dirt, dust, or biofilms.
  • User-friendly operation and handling.
  • Designed to be operated by non-specialized personnel.
  • Less sensitive to climatic conditions.
  • Easy to handle even in rooms that are not gas-tight sealed.
  • Operates with lower concentrated H2O2 products (7.5 – 8%) – No hazardous materials, no ADR transport and storage regulations.

Q: Are electronic devices damaged by aerosol disinfection with boosted hydrogen peroxide?

A: Various independent studies and our own experiences show that electronic devices such as PCs, tablets, flat screens, mobile phones, etc., are not affected by aerosol disinfection with hydrogen peroxide. In contrast, chlorine dioxide or peracetic acid solutions can compromise the integrity of electronic devices.

Q: Is a sporicidal Log 5-6 reduction possible with the Q-Jet CT-20 and Sanosil S015?

A: Yes, with appropriate dosing and programming, this goal can be achieved.

A: How long does an aerosol disinfection take with the Q-Jet devices?

A: The total duration consists of A) spraying time – the time it takes to aerosolize a specific amount of disinfectant in a room, and B) necessary contact and decay time. During the contact time, germs are actively reduced. Simultaneously, hydrogen peroxide breaks down into water and oxygen. This process takes a minimum of 120 minutes.

 

A: Can aerosol disinfection replace traditional cleaning or manual spray-wipe disinfection?

A: No, that’s not possible. While aerosol disinfection provides comprehensive coverage of all surfaces compared to wipe disinfection, it has limited penetration depth. Even small amounts of dirt residue significantly reduce the effectiveness of aHP disinfection, which is why thorough pre-cleaning cannot be skipped.
Aerosol technology represents an additional safety measure to mitigate microbiological risks.

A: Can aerosol disinfection be carried out in the presence of people (or animals)?

A: No, that’s not possible. (Unless they are protected by an ABEK-P3 full-face respirator.)

Q: What are the advantages of Sanosil disinfectants with boosted hydrogen peroxide compared to other products used for this purpose?

A: Sanosil Q-Dis (and S015) are excellent for whole-room disinfection. They:

 

  • Pose fewer health risks and issues compared to vaporized formaldehyde.
  • Are gentler on materials and have less odor compared to peracetic acid-hydrogen peroxide systems.
  • Are easier to establish in cycle and safer to handle than H2O2 vapor systems (VpHP).
  • Do not promote germ resistance like QAC products.
  • Have comprehensive tested efficacy (EN 17272 / AFNOR NFT 72-281 norm) — in contrast to most systems with anolyte, active chlorine, or hypochlorous acid.